2025

145. W. Hao, X. Hu, Q. Chen, B. Qin, Z. Tian, Z. Li, P. Hou, R. Zhao, H. Balci, S. Cui, J. Diao. Duplex unwinding mechanism of coronavirus MERS-CoV nsp13 helicases. Chem. Biomed. Imaging 3,  (2025).

144. O. Tyoe, C. Aryal, J. Diao. Cholesterol regulates vesicle clustering mediated by alpha-synuclein in a nonlinear fashion. Biophys. Rep. 11,  (2025). 

143. O. Tyoe, K. Zhang, J. Diao. Molecular dynamics simulation for membrane fusion. Methods Mol. Biol.  (2025).

142. K. Qiu, X. Xu, K. Zhang, J. Diao. Alternating cellular functions by optogenetic control of organelles. Methods Mol. Biol.  (2025).

141. Q. Chen, J. Diao. Super-resolution imaging of sub-cellular dynamics of drug molecules. Adv. Drug Deliv. Rev. 216, 115455 (2025).

2024

140. X.-Z. Yang, S. Yao, J. Wu, J. Diao, J.S. Kim, W. He, Z. Guo, Y. Chen. Recent advances in single fluorescent probes for monitoring dual organelles in two channels. Smart Mol. 2, e20240040 (2024). 

139. Prati, B.K. Kundu, R. Chen, J. Diao, Y. Sun. Near-infrared bioimaging using two-photon fluorescent probes. Adv. Healthc. Mater. 13, 2403272 (2024).

138. Z. Tang, X. Wu, J. Liu, L. Tian, X. Li, J. Diao, B. Ji, D. Li. Folding of N-terminally acetylated α-synuclein upon interaction with lipid membranes. Biophys. J. 123, 3698 (2024).

137. J. Guo, A. Zia, Q. Qiu, M. Norton, K. Qiu, J. Usuba, Z. Liu, M. Yi, S.T. Rich-New, M. Hagan, S. Fraden, G.D. Han, J. Diao, F. Wang, B. Xu. Cell-free non-equilibrium assembly for hierarchical protein/peptide nanopillars. J. Am. Chem. Soc. 146, 26102 (2024).

136. Y. Wang, Y.-S. Chan, E. Lee, D. Shi, C.-Y. Lee, J. Diao. Monitoring Escherichia coli in water through real-time LAMP on biochips. Micromachines 15, 1112 (2024).

135. Y. Wang, M. Chae, T.-J. Oh, K. Qiu, K. Mehta, A. Tan, N.-P. Tsai, D. Shi, K. Zhang, J. Diao. Sustainable synthesis of carbon dots via bio-waste recycling for biomedical imaging. Smart Med. 3, e20240012 (2024).

134. C. Wang, K. Zhang, B. Cai, J.E. Haller, K.E. Carnazza, J. Hu, C. Zhao, Z. Tian, X. Hu, D. Hall, J. Qiang, S. Hou, Z. Liu, J. Gu, Y. Zhang, K.B. Seroogy, J. Burré, Y. Fang, C. Liu, A.T. Brunger, D. Li, J. Diao. VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates. Nat. Cell Biol. 26, 1287 (2024).

133. Z. Tian, J. Diao. A matter of timing. eLife 13, e99181 (2024).

132. C. Zhao, J. Tu, C. Wang, W. Liu, J. Gu, Y. Yin, Y. Zhang, D. Li, J. Diao, Z.-J. Zhu, C. Liu. Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation. Natl. Sci. Rev. 11, nwae182 (2024).

131. C. Wang, C. Zhao, X. Hu, J. Qiang, Z. Liu, J. Gu, S. Zhang, D. Li, Y. Zhang, J. Burré, J. Diao, C. Liu. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine. eLife 13, RP97228 (2024).

130. J. Diao. Q&A with Jiajie Diao. Cell Rep. 43, 113741 (2024).

129. J. Diao, C.K. Yip, Q. Zhong. Recent advances in the molecular structures and function of the autophagosome-lysosome fusion machinery. Autophagy Rep. 3, 2305594 (2024).

128. M. Xue, L. Dong, H. Zhang, Y. Li, K. Qiu, Z. Zhao, M. Gao, L. Han, A.K.N. Chan, W. Li, K. Leung, K. Wang, S.P. Pokharel, Y. Qing, W. Liu, X. Wang, L. Ren, H. Bi, L. Yang, C. Shen, Z. Chen, L. Melstrom, H. Li, N. Timchenko, X. Deng, W. Huang, S.T. Rosen, J. Tian, Lin Xu, J Diao, C.-W. Chen, J. Chen, B. Shen, H. Chen, R. Su. METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation. J. Hematol. Oncol. 17, 7 (2024).

127. M. Wu, Y. Xiang, L. Tang, W. Li, X. Wang, Y. Du, W. Zuo, S. Zhang, Q. Hu, M. Wang, J. Diao, J. Wu, Y. Lai. Molecular imaging of aging-related 5-hydroxymethylcytosine in cell-free DNA at the single-copy level. Sens. Actuator B-Chem. 402, 135098 (2024).

2023

126. Q. Chen, L.-Y. Liu, Z. Tian, Z. Fang, K.-N. Wang, H. Chen, X. Shao, C. Zhang, W. Zou, F. Rowan, K. Qiu, B. Ji, J.-L. Guan, D. Li, Z.-W. Mao, J. Diao. Mitochondrial nucleoid condensates induce peripheral fission through high membrane curvature. Cell Rep. 42, 113472 (2023).

125. Y. Lai, C. Zhao, Z. Tian, C. Wang, J. Fan, X. Hu, J. Tu, T. Li, J. Leitz, R.A. Pfuetzner, Z. Liu, S. Zhang, Z. Su, J. Burré, D. Li, T.C. Südhof, Z.-J. Zhu, C. Liu, A.T. Brunger, J. Diao. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering. Proc. Natl. Acad. Sci. USA 120, e2310174120 (2023).

124. X. Xu, K. Qiu, Z. Tian, C. Aryal, F. Rowan, R. Chen, Y. Sun, J. Diao. Probing the dynamic crosstalk of lysosomes and mitochondria with structured illumination microscopy. TrAC Trends Anal. Chem. 169, 117370 (2023).

123. O. Tyoe, C. Aryal, J. Diao. Docosahexaenoic acid promotes vesicle clustering mediated by alpha-Synuclein via electrostatic interaction. Eur. Phys. J. E 46, 96 (2023).

122. R. Chen, K. Qiu, B.K. Kundu, G. Ding, G. Han, Y. Sun, J. Diao. Quantifying cell viability through organelle ratiometric probing. Chem. Sci. 14, 10236 (2023). Highlighted by: UC News 

121. R. Chen, K. Qiu, D.C.Y. Leong, B.K. Kundu, C. Zhang, P. Srivastava, K.E. White, G. Han, Z. Guo, C.G. Elles, J. Diao, Y. Sun. A general design of pyridinium-based fluorescent probes for enhancing two-photon microscopy. Biosens. Bioelectron. 239, 115604 (2023). Highlighted by: UC News 

120. Y. Wang, Y.-S. Chan, M. Chae, D. Shi, C.-Y. Lee, J. Diao. Programmable digital-microfluidic biochips for SARS-CoV-2 detection. Bioengineering 10, 923 (2023).

119. X. Shao, Z. Fang, M. Li, W. Zou, Q. Wang, C. Zhang, Y. Wei, Z. Tian, Y. Lai, Y. Cao, B. Ji, D. Li, Q. Chen, J. Diao. Graphene oxide nanosheets induce mitochondrial fragmentation by cutting through membrane. ACS Mater. Lett. 5, 2308 (2023).

118. C. Zhang, Z. Tian, R. Chen, F. Rowan, K. Qiu, Y. Sun, J.-L. Guan, J. Diao. Advanced imaging techniques for tracking drug dynamics at the subcellular level. Adv. Drug Deliv. Rev. 199, 114987 (2023).

117. R. Chen, L. Wang, G. Ding, G. Han, K. Qiu, Y. Sun, J. Diao. A constant conversion rate of endolysosomes revealed by a pH-sensitive fluorescent probe. ACS Sensors 8, 2068 (2023). Highlighted by: UC News

116. K. Qiu, Z. Tian, J. Diao. Monitoring lysosomal acidity. Nat. Chem. Biol. 19, 1434 (2023).

115. B. Bu, Z. Tian, D. Li, K. Zhang, W. Chen, B. Ji, J. Diao. Double-transmembrane domain of SNAREs decelerates the fusion by increasing the protein-lipid mismatch. J. Mol. Biol. 435, 168089 (2023).

114. K. Qiu, W. Zou, Z. Fang, Y. Wang, S. Bell, X. Zhang, Z. Tian, X. Xu, B. Ji, D. Li, T. Huang, J. Diao. 2D MoS2 and BN nanosheets damage mitochondria through membrane penetration. ACS Nano 17, 4716 (2023).

113. Y.-S. Chan, J. Diao, C.-Y. Lee. A pattern-control digital microfluidic bio-chip for fast thermal cycle in medical tests. 2023 IEEE International Symposium on Circuits and Systems (ISCAS), Monterey, CA, USA, 2023, pp. 1-4, doi: 10.1109/ISCAS46773.2023.10181466.

112. D. Li, J. Diao. Protein-membrane interaction at the pre-synapse. J. Mol. Biol. 435, 167905 (2023).

111. H. Fang, L. Hu, Q. Chen, S. Geng, C. Wang, M. Hao, Z. Tian, H. Chen, L. Liu, J.-L. Guan, Y. Chen, L. Dong, Z. Guo, W. He, J. Diao. An ER-targeted “reserve-release” fluorogen for topological quantification of reticulophagy. Biomaterials 292, 121929 (2023).

2022

110. K. Wu, W. Sun, D. Li, J. Diao, P. Xiu. Inhibition of amyloid nucleation by steric hindrance. J. Phys. Chem. B 126, 10045 (2022).

109. D.G. Gamage, K. Melikov, P. Munoz-Tello, T. Wherley, L. Focke, E. Leikina, E. Huffman, J. Diao, D.J. Kojetin, V. Prasad, L.V. Chernomordik, D.P. Millay. Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion. Proc. Natl. Acad. Sci. USA 119, e2202490119 (2022).

108. K. Qiu, A. Yadav, Z. Tian, Z. Guo, D. Shi, C.K. Nandi, J. Diao. Ultra-long-term super-resolution tracking of lysosomes in brain organoids by near-infrared noble metal nanoclusters. ACS Mater. Lett. 4, 1565 (2022).

107. K. Qiu, W. Zou, H. Fang, M. Hao, K. Mehta, Z. Tian, J.-L. Guan, K. Zhang, T. Huang, J. Diao. Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts. Nat. Commun. 13, 4303 (2022). Highlighted by: UC News 

106. G. Fang, H. Chen, X. Shao, H. Wang, D. Zhan, R. Wang, P. Meng, H. Fang, F. Liu, P. Ling, Z. Wu, J. Diao, Q. Yao, Q. Chen. Single image capture of bioactive ion crosstalk within inter-organelle membrane contacts at nanometer resolution. Small Methods 6, 2200321 (2022).

105. L. Wang, R. Chen, G. Han, X. Liu, T. Huang, J. Diao, Y. Sun. Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe. Exploration 2, 0210215 (2022).

104. Y. Wang, X. Hu, J. Long, J. Diao. Epigenetic optical sensing of 5-hydroxymethylcytosine at the single-molecule level. Sens. Actuator B-Chem. 358, 131500 (2022).

103. L. Wang, J. Diao. VAMP8 phosphorylation regulates lysosome dynamics in autophagy. Autophagy Rep. 1, 79 (2022).

102. K. Qiu, R. Seino, G. Han, M. Ishiyama, Y. Ueno, Z. Tian, Y. Sun, J. Diao. De novo design of a membrane-anchored probe for multi-dimensional quantification of endocytic dynamics. Adv. Healthc. Mater. 11, 2102185 (2022). Highlighted by: UC News

2021

101. C.M. Aryal, O. Tyoe, J. Diao. Lipid species dependent vesicles clustering caused by alpha-synuclein as revealed by single-vesicle imaging with total internal reflection fluorescence microscopy. Biophys. Rep. 7, 437 (2021).

100. Q. Chen, M. Hao, L. Wang, L. Li, Y. Chen, X. Shao, Z. Tian, R.A. Pfuetzner, Q. Zhong, A.T. Brunger, J.-L. Guan, J. Diao. Prefused lysosomes cluster on autophagosomes regulated by VAMP8. Cell Death Dis. 12, 939 (2021). 

99. J. Yan, Y. Wang, X. Li, D. Guo, Z. Zhao, G. Bai, J. Li, N. Huang, J. Diao, Y. Li, W. He, W. Liu, K. Tao. A bionic nano band-aid constructed by a three-stage self-assembly of peptides for rapid liver hemostasis. Nano Lett. 21, 7166 (2021).

98. K.-N. Wang, X. Shao, Z. Tian, L.-Y. Liu, C. Zhang, C.-P. Tan, J. Zhang, P. Ling, F. Liu, Q. Chen, J. Diao, Z.-W. Mao. A continuously add-on probe reveals a nonlinear enlargement of mitochondria in light-activated oncosis. Adv. Sci. 8, 2004566 (2021).

97. W. Zou, Q. Chen, J. Slone, L. Yang, X. Lou, J. Diao, T. Huang. Nanoscopic quantification of sub-mitochondrial morphology, mitophagy and mitochondrial dynamics in living cells derived from patients with mitochondrial diseases. J. Nanobiotechnol. 19, 136 (2021).

96. X. Zheng, J. Yan, W. You, F. Li, J. Diao, W. He, Y. Yao. De novo nano-erythrocyte structurally braced by biomimetic Au(I)-peptide skeleton for MDM2/MDMX predation towards augmented pulmonary adenocarcinoma immunotherapy. Small 17, 2100394 (2021).

95. Y. Du, Y. Lai, J. Liu, J. Diao. Epigenetic quantification of DNA 5-hydroxymethylcytosine using DNA hybridization-based single-molecule immunofluorescent imaging. Small Methods 5, 2100061 (2021).

94. Y. Tao, J. Xie, Q. Zhong, Y. Wang, S. Zhang, F. Luo, F. Wen, J. Xie, J. Zhao, X. Sun, H. Long, J. Ma, Q. Zhang, J. Long, X. Fang, Y. Lu, D. Li, M. Li, J. Zhu, B. Sun, G. Li, J. Diao, C. Liu. A novel partially-open state of SHP2 points to a “multiple gear” regulation mechanism. J. Biol. Chem. 296, 100538 (2021).

93. E. Lerner et al. FRET-Based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices. Elife 10, e60416 (2021).

92. D.J. Klionsky et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17, 1  (2021). 

91. J. Liu, B. Bu, M. Crowe, D. Li, J. Diao, B. Ji. Membrane packing defects in synaptic vesicles recruit complexin and synuclein. Phys. Chem. Chem. Phys. 23, 2117 (2021).

90. H. Fang, S. Geng, M. Hao, Q. Chen, M. Liu, C. Liu, Z. Tian, C. Wang, T. Takebe, J.-L. Guan, Y. Chen, Z. Guo, W. He, J. Diao. Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells. Nat. Commun. 12, 109 (2021). 

2020

89. Q. Chen, H. Fang, X. Shao, Z. Tian, S. Geng, Y. Zhang, H. Fan, P. Xiang, J. Zhang, X. Tian, K. Zhang, W. He, Z. Guo, J. Diao. A dual-labeling molecular probe to track functional mitochondria-lysosome interactions in live cells. Nat. Commun. 11, 6290 (2020). 

88. K. Wu, D. Li, P. Xiu, B. Ji, J. Diao. O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect. Phys. Biol. 18, 016002 (2020).

87. L.-Y. Liu, H. Fang, Q. Chen, M. H.-Y. Chan, M. Ng, K.-N. Wang, W. Liu, Z. Tian, J. Diao, Z.-W. Mao, V. W.-W. Yam. Multiple-color platinum complex with super-large Stokes shift for super-resolution imaging of autolysosome escape. Angew. Chem. Int. Ed. 59, 19229 (2020).

86. M. Li, T.-J. Oh, H. Fan, J. Diao, K. Zhang. Syntaxin clustering and optogenetic control for synaptic membrane fusion. J. Mol. Biol. 432, 4773 (2020). 

85. K. Qiu, Y. Du, J. Liu, J.-L. Guan, H. Chao, J. Diao. Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles. Theranostics 10, 6072 (2020). 

84. X. Shao, Q. Chen, L. Hu, Z. Tian, L. Liu, F. Liu, F. Wang, P. Ling, Z.-W. Mao, J. Diao.  Super-resolution quantification of nanoscale damage to mitochondria in live cells. Nano Res. 13, 2149 (2020). 

83. Q. Chen, X. Shao, M. Hao, R. Guan, Z. Tian, M. Li, C. Wang, L. Ji, H. Chao, J.-L. Guan, J. Diao. Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy. Biomaterials 250, 120059 (2020). 

82. J. Sun, K. Du, J. Diao, X. Cai, F. Feng, S. Wang. GSH and H2O2 co-activatable mitochondria-targeted photodynamic therapy under normoxia and hypoxia. Angew. Chem. Int. Ed. 59, 12122 (2020). 

81. Y. Du, Y. Wang, X. Hu, J. Liu, J. Diao. Single-molecule quantification of 5-methylcytosine and 5-hydroxymethyicytosine in cancer genome. View 1, e9 (2020). 

80. B. Cai, J. Liu, Y. Zhao, X. Xu, B. Bu, D. Li, L. Zhang, W. Dong, B. Ji, J. Diao. Single-vesicle imaging quantifies calcium’s regulation of nanoscale vesicle clustering mediated by α-synuclein. Microsyst. Nanoeng. 6, 38 (2020). 

79. C. Wang, J. Tu, S. Zhang, B. Cai, Z. Liu, S. Hou, Q. Zhong, X. Hu, W. Liu, G. Li, Z. Liu, L. He, J. Diao, Z.-J. Zhu, D. Li, C. Liu. Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly. Nat. Commun. 11, 1531 (2020).

2019

78. H. Fang, S. Yao, Q. Chen, C. Liu, Y. Cai, S. Geng, Y. Bai, Z. Tian, A.L. Zacharias, T. Takebe, Y. Chen, Z. Guo, W. He, J. Diao. De novo-designed near-infrared nanoaggregates for super-resolution monitoring of lysosomes in cells, in whole organoids, and in vivo. ACS Nano 13, 14426 (2019). 

77. Z. Wang, H. Fan, X. Hu, J. Khamo, J. Diao, K. Zhang, T.V. Pogorelov. Coaction of electrostatic and hydrophobic interactions: dynamic structural constraints on disordered TrkA juxtamembrane domain. J. Phys. Chem. B 123, 10709 (2019). 

76. P. Brown, RELISH Consortium, Y. Zhou. Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database baz085 (2019).  

75. N. Brose, A. Brunger, D. Cafiso, E.R. Chapman, J. Diao, F.M. Hughson, M.B. Jackson, R. Jahn, M. Lindau, C. Ma, J. Rizo, Y.-K. Shin, T.H. Söllner, L. Tamm, T.-Y. Yoon, Y. Zhang. Synaptic vesicle fusion: today and beyond. Nat. Struct. Mol. Biol. 26, 663 (2019).

74. D.-F. Ma, C.-H. Xu, W.-Q. Hou, C.-Y. Zhao, J.-B. Ma, X.-Y. Huang, Q. Jia, L. Ma, J. Diao, C. Liu, M. Li, Y. Lu. Detecting single molecule dynamics on lipid membranes with quenchers-in-a-liposome FRET. Angew. Chem. Int. Ed. 58, 5577 (2019). 

73. X. Li, X. Tong, W. Lu, D. Yu, J. Diao, Q. Zhao. Label-free detection of early oligomerization of α-synuclein and its mutants A30P/E46K through solid-state nanopores. Nanoscale 11, 6480 (2019). 

72. Q. Chen, X. Shao, Z. Tian, Y. Chen, P. Mondal, F. Liu, F. Wang, P. Ling, W. He, K. Zhang, Z. Guo, J. Diao. Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discovery. Nano Res. 12, 1009 (2019).

71. B. Cai, L. Yu, S.R. Sharum, K. Zhang, J. Diao. Single-vesicle measurement of protein-induced membrane tethering. Colloids Surf. B-Biointerfaces 177, 267 (2019).

70. Z. Tian, J. Gong, M. Crowe, M. Lei, D. Li, B. Ji, J. Diao. Biochemical studies of membrane fusion at the single-vesicle level. Prog. Lipid Res. 73, 92 (2019).

69. Q. Wang, X. Zhai, M. Crowe, L. Guo, Y. Li, D. Li, L. Zhang, J. Diao, B. Ji. Heterogeneous oxidization of graphene nanosheets damages membrane. Sci. China-Phys. Mech. Astron. 62, 064611 (2019).

68. J. Khamo, V. Krishnamurthy, Q. Chen, J. Diao, K. Zhang. Optogenetic delineation of receptor tyrosine kinase subcircuits during PC12 cell differentiation. Cell Chem. Biol. 26, 400 (2019).

67. Y. Hu, Z. Tian, J. Diao. Single-molecule fluorescence measurement of SNARE-mediated vesicle fusion. Methods Mol. Biol. 1860,  335 (2019).

2018

66. Q. Chen, C. Jin, X. Shao, R. Guan, Z. Tian, C. Wang, F. Liu, P. Ling, J. Guan, L. Ji, F. Wang, H. Chao, J. Diao. Super-resolution tracking of mitochondrial dynamics with an Iridium(III) luminophore. Small 14, 1802166 (2018).

65. E. Leikina, D.G. Gamage, V. Prasad, J. Goikberg, M. Crowe, J. Diao, M.M. Kozlov, L.V. Chernomordik, D.P. Millay. Myomaker and Myomerger work independently to control distinct steps of membrane remodeling during myoblast fusion. Dev. Cell  46, 767 (2018).

64. B. Bu, M. Crowe, J. Diao, B. Ji, D. Li. Cholesterol suppresses membrane leakage by decreasing water penetrability. Soft Matter 14, 5277 (2018).

63. X. Feng, S.-J. Hsu, A. Bhattacharjee, Y. Wang, J. Diao, C.M. Price. CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells. Nat. Commun. 9, 2827 (2018).

62. Z. Tian, M. Crowe, L. Shao, P. Zhang, L. Zhang, Q. Zhao, J. Diao. Interface colloidal deposition of nanoparticle wire structures. Part. Part. Syst. Charact. 35, 1800098 (2018).

61. K. Qiu, L. Ke, X. Zhang, Y. Liu, T.W. Rees, L. Ji, J. Diao, H. Chao. Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent Iridium(III) complexes. Chem. Commun. 54, 2421 (2018).

60. M. Crowe, Z. Tian, P. Zhang, J.J. Diao. Pristine graphene modulation of vertical colloidal deposition for gold nanoparticle wires. Colloids Surf. A-Physicochem. Eng. Asp. 544, 159 (2018).

2017

59. X. Jiang, C. Hu, K. Ferchen, J. Nie, X. Cui, C.-H. Chen, L. Cheng, Z. Zuo, W. Seibel, C. He, Y. Tang, J.R. Skibbe, M. Wunderlich, W.C. Reinhold, L. Dong, C. Shen, S. Arnovitz, B. Ulrich, J. Lu, H. Weng, R. Su, H. Huang, Y. Wang, C. Li, X. Qin, J. Mulloy, Y. Zheng, J. Diao, J. Jin, C. Li, P.P. Liu, C. He, Y. Chen, J. Chen. Targeted inhibition of STAT/TET1 axis as a potent therapeutic strategy for acute myeloid leukemia. Nat. Commun. 8, 2099 (2017).

58. A. Bhattacharjee, Y. Wang, J. Diao, C.M. Price. Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST. Nucleic Acids Res. 45, 12311 (2017).

57. C.-X. Song, S. Yin, L. Ma, A. Wheeler, Y. Chen, Y. Zhang, B. Liu, J. Xiong, W. Zhang, J. Hu, Z. Zhou, B. Dong, Z. Tian, S.S. Jeffrey, M.-S. Chua, S. So, W. Li, Y. Wei, J. Diao, D. Xie, S.R. Quake. 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages. Cell Res. 27, 1231 (2017).

56. B. Bu, X. Tong, D. Li, Y. Hu, W. He, C. Zhao, R. Hu, X. Li, Y. Shao, C. Liu, Q. Zhao, B. Ji, J. Diao. N-terminal acetylation preserves α-synuclein from oligomerization by blocking intermolecular hydrogen bonds. ACS Chem. Neurosci. 8, 2145 (2017).

55. M. Crowe, Y. Lai, Y. Wang, J. Lu, M. Zhao, Z. Tian, J. Long, P. Zhang, J. Diao. A proteoliposome method for assessing nanotoxicity on synaptic fusion and membrane integrity. Small Methods 1, 1700207, (2017).   Highlighted by: Journal Cover

54. Y. Qing, Z. Tian, Y. Bi, Y. Wang, J. Long, C.-X. Song, J. Diao. Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine. Bioessays 39, 1700010 (2017).

53. Y. Hu, Y. Lai, Y. Wang, M. Zhao, Y. Zhang, M. Crowe, Z. Tian, J. Long, J. Diao. SNARE-reconstituted liposomes as controllable zeptoliter nanoreactors for macromolecules. Adv. Biosyst. 1, 1600018 (2017).   Highlighted by: Advanced Science News

52. B. Bu, D. Li, J. Diao, B. Ji. Mechanics of water pore formation in lipid membrane under electric field. Acta Mech. Sin. 33, 234 (2017).

51. J. Diao, L. Li, Y. Lai, Q. Zhong. In vitro reconstitution of autophagosome-lysosome fusion. Methods Enzymol. 587, 365 (2017).

2016

50. Y. Wang, L. Li, C. Hou, Y. Lai, J. Long, J. Liu, Q. Zhong, J. Diao. SNARE-mediated membrane fusion in autophagy. Semin. Cell Dev. Biol. 60, 97 (2016).

49. J. Gong, Y. Lai, X. Li, M. Wang, J. Leitz, Y. Hu, Y. Zhang, U.B. Choi, D. Cipriano, R.A. Pfuetzner, T.C. Südhof, X. Yang, A.T. Brunger, J. Diao. C-terminal domain of mammalian complexin-1 localizes to highly curved membranes. Proc. Natl. Acad. Sci. USA 113, E7590 (2016).

48. Z. Tian, Y. Hu, J. Long, J. Liu, J. Diao. Single-molecule biophysical studies of neurotransmitter release. Prog. Biochem. Biophys. 43, 946 (2016). [in Chinese]

47. X. Li, R. Hu, J. Li, X. Tong, J.J. Diao, D. Yu, Q. Zhao. Non-sticky translocation of bio-molecules through Tween 20-coated solid-state nanopores in a wide pH range. Appl. Phys. Lett. 109, 143105 (2016).

46. Y. Lai, U.B. Choi, Y. Zhang, R.A. Pfuetzner, A.L. Wang, J. Diao, A.T. Brunger. N-terminal domain of complexin independently activates calcium-triggered fusion. Proc. Natl. Acad. Sci. USA 113, E4698 (2016).

45. S. Malmersjö, S. Di Palma, J. Diao, Y. Lai, R.A. Pfuetzner, A.L. Wang, M.A. McMahon, A. Hayer, M. Porteus, B. Bodenmiller, A.T. Brunger, T. Meyer. Phosphorylation of residues inside the SNARE complex terminates secretory vesicle fusion. EMBO J. 35, 1810 (2016).

44. C. Wang, C. Zhao, D. Li, Z. Tian, Y. Lai, J. Diao, C. Liu. Versatile structures of α-synuclein. Front. Mol. Neurosci. 9, 48 (2016).

43. C.-X. Song, J. Diao, A.T. Brunger, S.R. Quake. Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation. Proc. Natl. Acad. Sci. USA 113, 4338 (2016).   Highlighted by: PNAS

42. R. Hu, J. Diao, J. Li, Z. Tang, X. Li, J. Leitz, J. Long, J. Liu, D. Yu, Q. Zhao. Intrinsic and membrane-facilitated oligomerization of α-synuclein revealed by a label-free detection through solid-state nanopores. Sci. Rep. 6, 20776 (2016).

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